个人简介
学术兼职
中国微生物学会分子微生物学及生物工程专业委员会委员、中国化工学会生物化工青年工作委员会委员
Synthetic and Systems Biotechnology期刊编委
《生物工程学报》期刊编委
《合成生物学》期刊编委
荣誉奖励
第五届中国科协“青年人才托举工程”
第五届“闵恩泽能源化工奖”青年进步奖
研究领域和方向
以天然产物、生物材料等化合物的微生物合成为研究目标，变革传统生产模式，利用代谢工程、合成生物学、酶工程等手段，构建微生物细胞工厂，解决生物合成的关键科学问题，提高生产效率，旨在实现上述高附加值产品的绿色生物制造，推动工业化生产。主要研究包括： 1. 解析天然产物在微生物中的合成途径，实现新化合物的微生物合成 2. 开发高效基因组装和基因组编辑技术 3. 代谢途径构建与调控 4. 开发针对特定化合物的底盘细胞改造技术，构建高效微生物细胞工厂 5. 生物材料的微生物生产
教育背景
2010/09-2015/07：清华大学，生命科学学院，理学博士 2006/09-2010/06：山东大学，生命科学学院，理学学士
工作履历
2024/01 - 至今：yl6809永利官网，yl6809永利官网，长聘副教授/特别研究员 2018/05-2023/12： yl6809永利官网，yl6809永利官网，预聘副教授/特别研究员 2016/10-2017/11：美国麻省理工学院，化学工程系，博士后 2015/07-2018/04：yl6809永利官网，化学工程与技术，师资博士后
研究成果
主持国家自然科学基金等国家级项目4项、国家重点研发计划子课题2项；参与国家自然科学基金项目、973项目等4项。迄今在Metabolic Engineering, ACS Catalysis, Trends in Biotechnology, Biotechnology Advances等国内外本领域高水平期刊发表学术论文30余篇，获授权发明专利 5项。参编出版《合成生物学》教材，参与出版学术专著4部。 主要科研项目 1. 大肠杆菌耐受单萜的动态调控系统建立及产物合成强化，国家自然科学基金面上项目，主持 2. 酵母合成三萜化合物关键酶的量效关系与协同调控，国家自然科学基金面上项目，主持 3. 合成植物天然产物的微生物细胞工厂构建及应用示范，国家重点研发计划，子课题负责人 4. 新天然与人工产物的定向挖掘和高效合成的平台技术，国家重点研发计划，子课题负责人 5. 中国科协“青年人才托举工程”，主持 6. 酵母生产五环三萜类化合物的胞外转运与合成强化，国家自然科学基金青年基金，主持 7. yl6809永利官网创新人才专项计划项目，主持 代表性论文 1. Yu Yuan, Rasool Aamir, Liu Haoran, Lv Bo, Chang Pengcheng, Song Hao, Wang Ying*, Li Chun*. Engineering Saccharomyces cerevisiae for High Yield Production of α-amyrin via Synergistic Remodeling of α-amyrin Synthase and Expanding the Storage Pool. Metabolic Engineering, 2020, 62: 72-83 (IF=8.8) 2. Tan Dan#, Wang Ying#, Tong Yi, Chen Guo-Qiang*. Grand Challenges for Industrializing Polyhydroxyalkanoates (PHAs), Trends in Biotechnology, 2021, 39：953-963 (ESI高被引论文，IF=21.9) 3. Sun Wentao, Xue Haijie, Liu Hu, Lv Bo, Yu Yang*, Wang Ying*, Huang Meilan, Li Chun*. Controlling Chemo- and Regioselectivity of a Plant P450 in Yeast Cell toward Rare Licorice Triterpenoid Biosynthesis, ACS Catalysis, 2020, 10: 4253-4260 (IF=13.7) 4. Zhu Ying, Zhou Chen, Liu Xia, Li Xinying, Shi Caifang, Zhang Yapeng, Wang Ying*, Li Chun*. Aided‐efflux and high production of β‐amyrin realized by β‐cyclodextrin in situ synthesized on surface of Saccharomyces cerevisiae, Biotechnology and Bioengineering, 2023, 120: 1147-1158(IF=4.4) 5. Wang Ying, Ling Chen, Chen Yong, Jiang Xiaoran, Chen Guo-Qiang *. Microbial engineering for easy downstream processing. Biotechnology Advances, 2019, 37: 107365 (IF=17.7) 6. Zhang Xu, Lin Yina, Wu Qiong, Wang Ying*, Chen Guo-Qiang*. Synthetic Biology and Genome Editing Tools for Improving PHA Metabolic Engineering, Trends in Biotechnology, 2019, 38: 689-700 (IF=21.9) 7. Li Chenyi#, Gao Xiaopeng#, Peng Xiao, Li Jinlin, Bai Wenxin, Zhong Jiadong, He Mengchao, Xu Ke, Wang Ying*, Li Chun*, Intelligent microbial cell factory with genetic pH shooting (GPS) for cell self responsive base/acid regulation. Microbial Cell Factories, 2020, 19: 202 (IF=6.4) 8. Luo Yan, Jiang Yaozhu, Chen Linhao, Li Chun, Wang Ying*. Applications of protein engineering in the microbial synthesis of plant triterpenoids. Synthetic and Systems Biotechnology, 2023, 8: 20-32 (IF=4.7) 9. Zhu Ying, Zhou Chen, Wang Ying*, Li Chun*, Transporter Engineering for Microbial Manufacturing. Biotechnology Journal, 2020, 15, 1900494 (IF=5.7) 10. Alkhadrawi Adham M., Wang Ying*, Li Chun*. In-silico screening of potential target transporters for glycyrrhetinic acid (GA) via deep learning prediction of drug-target interactions. Biochemical Engineering Journal, 2022, 181:108375 (IF=4.4) 11. Jia Nan#, Li Jingzhi#, Zang Guowei, Yu Yuan, Jin Xiaojv, He Yuna, Feng Meilin, Na Xuemei, Wang Ying*, Li Chun*. Engineering Saccharomyces cerevisiae for high-efficient production of ursolic acid via cofactor engineering and acetyl-CoA optimization. Biochemical Engineering Journal, 2024, 109189. (IF=4.4) 12. Li Jinling#, Wang Shuai#, Miao Yinan, Wan Ya, Li Chun*, Wang Ying*. Mining and modification of Oryza sativa-derived squalene epoxidase for improved β-amyrin production in Saccharomyces cerevisiae. Journal of Biotechnology, 2023, 375:1-11（IF=4.1） 13. Wang Ying#, Chung Ahleum#, Chen Guo-Qiang*. Synthesis of medium-chain-length polyhydroxyalkanoate homopolymers, random copolymers, and block copolymers by an engineered strain of Pseudomonas entomophila. Advanced Healthcare Materials, 2017, 6: 1601017 (IF=11.1) 14. Wang Ying, Wu Hong, Jiang Xiaoran, Chen Guo-Qiang*. Engineering Escherichia coli for enhanced production of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) in larger cellular space. Metabolic Engineering, 2014, 25: 183-193 (IF=8.8) 15. Wang Ying#, Li Yan#, Xua Tuan, Shi Zhenyu*, Wu Qiong*. Experimental evidence for growth advantage and metabolic shift stimulated by photophosphorylation of proteorhodopsin expressed in Escherichia coli at anaerobic condition. Biotechnology and Bioengineering, 2015, 112: 947-956 (IF=4.4)